Figure 3. Microarray analyses of gene expression in head kidney (HK), liver (L) and spleen (SP). Pooled samples were analysed using uninfected fish as a common reference. A – log-expression ratios. Significantly up- and down-regulated genes (p < 0.05, t-test, 12 spot replicates per gene) are highlighted with red and green scales, NS is not significant. B: mean expression profiles of nine immunoglobulins designated by the Unigene clusters and most similar mammalian genes: Omy 9391 (Ig kappa chain V-III region VG), Omy 416 (Ig kappa chain V-IV region JI), Omy 23312 (Ig kappa chain V-IV region B17-1), Omy 9391 (Ig kappa chain C region), Omy 30091 (Ig kappa chain V-IV region Len), Ssa 709 (Ig kappa chain V-IV region B17-2), Ssa 78 (Ig heavy chain V-III region HIL), Omy 11287 (Ig mu heavy chain disease protein), Ssa 709 (Ig kappa chain V-I region WEA) Data are mean log-expression ratios ± SE, significant differences from zero (p < 0.05) are indicated with *.