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Immune correlates of CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption
Huang, K., Loutfy, M., Tsoukas, C., Bernard, N. (2008) BMC Infectious Diseases.
TABLE CAPTION
Table 1. Correlation between baseline immunological parameters and CD4 count change from baseline to nadir during TI
T-cell compartment Proliferative Stimulus/Phenotypic Markers Expression* Correlation with CD4 count change from baseline to nadir during TI**
CD4 anti-CD3 -0.07 (p = 0.87)
SEB 0.43 (p = 0.30)
CMV -0.59 (p = 0.045)***
Gag p55 peptide pool -0.40 (p = 0.17)
%CD57+ -0.69 (p = 0.0095)***
CD57+ MFI -0.03 (p = 0.93)
%CD28 -0.38 (p = 0.19)
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Immune correlates of CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption
Huang, K., Loutfy, M., Tsoukas, C., Bernard, N. (2008) BMC Infectious Diseases.
TABLE CAPTION
Table 1. Correlation between baseline immunological parameters and CD4 count change from baseline to nadir during TI
T-cell compartment Proliferative Stimulus/Phenotypic Markers Expression* Correlation with CD4 count change from baseline to nadir during TI**
CD4 anti-CD3 -0.07 (p = 0.87)
SEB 0.43 (p = 0.30)
CMV -0.59 (p = 0.045)***
Gag p55 peptide pool -0.40 (p = 0.17)
%CD57+ -0.69 (p = 0.0095)***
CD57+ MFI -0.03 (p = 0.93)
%CD28 -0.38 (p = 0.19)
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Immune correlates of CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption
Huang, K., Loutfy, M., Tsoukas, C., Bernard, N. (2008) BMC Infectious Diseases.
TABLE CAPTION
Table 1. Correlation between baseline immunological parameters and CD4 count change from baseline to nadir during TI
T-cell compartment Proliferative Stimulus/Phenotypic Markers Expression* Correlation with CD4 count change from baseline to nadir during TI**
CD4 anti-CD3 -0.07 (p = 0.87)
SEB 0.43 (p = 0.30)
CMV -0.59 (p = 0.045)***
Gag p55 peptide pool -0.40 (p = 0.17)
%CD57+ -0.69 (p = 0.0095)***
CD57+ MFI -0.03 (p = 0.93)
%CD28 -0.38 (p = 0.19)
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Immune correlates of CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption
Huang, K., Loutfy, M., Tsoukas, C., Bernard, N. (2008) BMC Infectious Diseases.
TABLE CAPTION
Table 1. Correlation between baseline immunological parameters and CD4 count change from baseline to nadir during TI
T-cell compartment Proliferative Stimulus/Phenotypic Markers Expression* Correlation with CD4 count change from baseline to nadir during TI**
CD4 anti-CD3 -0.07 (p = 0.87)
SEB 0.43 (p = 0.30)
CMV -0.59 (p = 0.045)***
Gag p55 peptide pool -0.40 (p = 0.17)
%CD57+ -0.69 (p = 0.0095)***
CD57+ MFI -0.03 (p = 0.93)
%CD28 -0.38 (p = 0.19)
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Immune correlates of CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption
Huang, K., Loutfy, M., Tsoukas, C., Bernard, N. (2008) BMC Infectious Diseases.
TABLE CAPTION
Table 1. Correlation between baseline immunological parameters and CD4 count change from baseline to nadir during TI
T-cell compartment Proliferative Stimulus/Phenotypic Markers Expression* Correlation with CD4 count change from baseline to nadir during TI**
CD4 anti-CD3 -0.07 (p = 0.87)
SEB 0.43 (p = 0.30)
CMV -0.59 (p = 0.045)***
Gag p55 peptide pool -0.40 (p = 0.17)
%CD57+ -0.69 (p = 0.0095)***
CD57+ MFI -0.03 (p = 0.93)
%CD28 -0.38 (p = 0.19)
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Immune correlates of CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption
Huang, K., Loutfy, M., Tsoukas, C., Bernard, N. (2008) BMC Infectious Diseases.
TABLE CAPTION
Table 1. Correlation between baseline immunological parameters and CD4 count change from baseline to nadir during TI
T-cell compartment Proliferative Stimulus/Phenotypic Markers Expression* Correlation with CD4 count change from baseline to nadir during TI**
CD4 anti-CD3 -0.07 (p = 0.87)
SEB 0.43 (p = 0.30)
CMV -0.59 (p = 0.045)***
Gag p55 peptide pool -0.40 (p = 0.17)
%CD57+ -0.69 (p = 0.0095)***
CD57+ MFI -0.03 (p = 0.93)
%CD28 -0.38 (p = 0.19)
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Immune correlates of CD4 decline in HIV-infected patients experiencing virologic failure before undergoing treatment interruption
Huang, K., Loutfy, M., Tsoukas, C., Bernard, N. (2008) BMC Infectious Diseases.
TABLE CAPTION
Table 1. Correlation between baseline immunological parameters and CD4 count change from baseline to nadir during TI
T-cell compartment Proliferative Stimulus/Phenotypic Markers Expression* Correlation with CD4 count change from baseline to nadir during TI**
CD4 anti-CD3 -0.07 (p = 0.87)
SEB 0.43 (p = 0.30)
CMV -0.59 (p = 0.045)***
Gag p55 peptide pool -0.40 (p = 0.17)
%CD57+ -0.69 (p = 0.0095)***
CD57+ MFI -0.03 (p = 0.93)
%CD28 -0.38 (p = 0.19)
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Cytokine, activation marker, and chemokine receptor expression by individual CD4+ memory T cells in rheumatoid arthritis synovium
Nanki, T., E Lipsky, P. (2000) Arthritis Research.
TABLE CAPTION
Table 1. Frequencies of cytokine and activation marker expression by CD4+ DC45RO+ T cells in synovial tissue of RA patients
IL-2IL-4IL-6IL-10IL-13IFN-γTNF-αLT-αCD154TRANCE
RA1 (n = 50)0 (0)0 (0)0 (0)7 (14)0 (0)11 (22)0 (0)6 (12)7 (14)8 (16)
RA2 (n = 39)0 (0)0 (0)0 (0)5 (13)1 (3)3 (8)0 (0)1 (3)10 (26)1 (3)
RA3 (n = 63)0 (0)0 (0)0 (0)4 (6)4 (6)4 (6)3 (5)4 (6)14 (22)3 (5)
Total (n = 152)0 (0)0 (0)0 (0)16 (11)5 (3)18 (12)3 (2)11 (7)31 (20)12 (8)
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Human cerebrospinal fluid contains CD4+ memory T cells expressing gut- or skin-specific trafficking determinants: relevance for immunotherapy
Kivisäkk, P., Tucky, B., Wei, T., Campbell, J., Ransohoff, R. (2006) BMC Immunology.
TABLE CAPTION
Table 1. Expression of trafficking determinants on CD4+ memory1 T cells in blood and CSF
CLAIntegrin α4β7CCR4CCR9
BloodCSFBloodCSFBloodCSFBloodCSF
NINDMean14.211.533.017.959.841.78.05.1
SD6.14.35.93.010.88.22.84.3
n1010445588
MSMeann.d.n.d.n.d.n.d.69.648.4n.d.n.d.
SD11.515.3
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Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function
Brennan, F., Smith, N., Owen, S., Li, C., Amjadi, P., Green, P., Andersson, A., Palfreeman, A., Hillyer, P., Foey, A., Beech, J., Feldmann, M. (2008) Arthritis Research & Therapy.
TABLE CAPTION
Table 1. Expression of activation markers, adhesion molecules and chemokine receptors in CD4+CD45RO+ Tck cells
Cell phenotype Median MFI (range)/percentage positive (%) index Changea P n
Day 0 Day 8
CD25 8.0 (2–49)/9% 61 (6–884)/18% 7.5 <0.0001 40
CD69 5.0 (2–43)/1.1% 41 (5–552)/26.7% 8 <0.0001 41
HLA-DR 19 (4–130)/9% 60 (11–238)/15% 3 0.0052 15
CD62L 22 (8–255)/17% 339 (7–1,040)/58% 15 <0.0001 31
CD18 107 (9–1,026)/97.5% 319 (53–2,040)/98.5% 3 0.0085 21
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Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function
Brennan, F., Smith, N., Owen, S., Li, C., Amjadi, P., Green, P., Andersson, A., Palfreeman, A., Hillyer, P., Foey, A., Beech, J., Feldmann, M. (2008) Arthritis Research & Therapy.
TABLE CAPTION
Table 1. Expression of activation markers, adhesion molecules and chemokine receptors in CD4+CD45RO+ Tck cells
Cell phenotype Median MFI (range)/percentage positive (%) index Changea P n
Day 0 Day 8
CD25 8.0 (2–49)/9% 61 (6–884)/18% 7.5 <0.0001 40
CD69 5.0 (2–43)/1.1% 41 (5–552)/26.7% 8 <0.0001 41
HLA-DR 19 (4–130)/9% 60 (11–238)/15% 3 0.0052 15
CD62L 22 (8–255)/17% 339 (7–1,040)/58% 15 <0.0001 31
CD18 107 (9–1,026)/97.5% 319 (53–2,040)/98.5% 3 0.0085 21
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Quantification of the virus-host interaction in human T lymphotropic virus I infection
Asquith, B., Mosley, A., Heaps, A., Tanaka, Y., Taylor, G., McLean, A., Bangham, C. (2005) Retrovirology.
TABLE CAPTION
Table 1. Tax expression in CD4+ lymphocytes is 2.5–3 fold higher in HAM/TSP patients than ACs of comparable proviral load
PatientProviral load (% PBMC)Rate of CTL lysis (per CD8+ cell per day)%Tax expression (Tax+CD4+/CD4+)Mean Tax expressionFold Increase in Tax Expression (HAM÷AC)
Group 1ACHBD0.00.2200.11.32.8
HT1.00.0623.1
HY0.40.0650.6
HAMTAQ1.00.0832.73.5
TAY2.20.2984.4
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Quantification of the virus-host interaction in human T lymphotropic virus I infection
Asquith, B., Mosley, A., Heaps, A., Tanaka, Y., Taylor, G., McLean, A., Bangham, C. (2005) Retrovirology.
TABLE CAPTION
Table 1. Tax expression in CD4+ lymphocytes is 2.5–3 fold higher in HAM/TSP patients than ACs of comparable proviral load
PatientProviral load (% PBMC)Rate of CTL lysis (per CD8+ cell per day)%Tax expression (Tax+CD4+/CD4+)Mean Tax expressionFold Increase in Tax Expression (HAM÷AC)
Group 1ACHBD0.00.2200.11.32.8
HT1.00.0623.1
HY0.40.0650.6
HAMTAQ1.00.0832.73.5
TAY2.20.2984.4
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Quantification of the virus-host interaction in human T lymphotropic virus I infection
Asquith, B., Mosley, A., Heaps, A., Tanaka, Y., Taylor, G., McLean, A., Bangham, C. (2005) Retrovirology.
TABLE CAPTION
Table 1. Tax expression in CD4+ lymphocytes is 2.5–3 fold higher in HAM/TSP patients than ACs of comparable proviral load
PatientProviral load (% PBMC)Rate of CTL lysis (per CD8+ cell per day)%Tax expression (Tax+CD4+/CD4+)Mean Tax expressionFold Increase in Tax Expression (HAM÷AC)
Group 1ACHBD0.00.2200.11.32.8
HT1.00.0623.1
HY0.40.0650.6
HAMTAQ1.00.0832.73.5
TAY2.20.2984.4
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Quantification of the virus-host interaction in human T lymphotropic virus I infection
Asquith, B., Mosley, A., Heaps, A., Tanaka, Y., Taylor, G., McLean, A., Bangham, C. (2005) Retrovirology.
TABLE CAPTION
Table 1. Tax expression in CD4+ lymphocytes is 2.5–3 fold higher in HAM/TSP patients than ACs of comparable proviral load
PatientProviral load (% PBMC)Rate of CTL lysis (per CD8+ cell per day)%Tax expression (Tax+CD4+/CD4+)Mean Tax expressionFold Increase in Tax Expression (HAM÷AC)
Group 1ACHBD0.00.2200.11.32.8
HT1.00.0623.1
HY0.40.0650.6
HAMTAQ1.00.0832.73.5
TAY2.20.2984.4
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Quantification of the virus-host interaction in human T lymphotropic virus I infection
Asquith, B., Mosley, A., Heaps, A., Tanaka, Y., Taylor, G., McLean, A., Bangham, C. (2005) Retrovirology.
TABLE CAPTION
Table 1. Tax expression in CD4+ lymphocytes is 2.5–3 fold higher in HAM/TSP patients than ACs of comparable proviral load
PatientProviral load (% PBMC)Rate of CTL lysis (per CD8+ cell per day)%Tax expression (Tax+CD4+/CD4+)Mean Tax expressionFold Increase in Tax Expression (HAM÷AC)
Group 1ACHBD0.00.2200.11.32.8
HT1.00.0623.1
HY0.40.0650.6
HAMTAQ1.00.0832.73.5
TAY2.20.2984.4
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Expression and functional effects of Eph receptor tyrosine kinase A family members on Langerhans like dendritic cells
Munthe, E., Finne, E., Aasheim, H. (2004) BMC Immunology.
TABLE CAPTION
Table 1. Expression of differentiation and activation markers on re-stimulated CD4+ cells
IFN-g, % posIL4, % posCD25, % pos
CD19-Fc, 1:1003.02.310.3
ephrin-A4-Fc, 1:1001.91.46.1
CD19-Fc, 1:1010.22.619.3
ephrin-A4-Fc, 1:107.42.117.3
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Expression and functional effects of Eph receptor tyrosine kinase A family members on Langerhans like dendritic cells
Munthe, E., Finne, E., Aasheim, H. (2004) BMC Immunology.
TABLE CAPTION
Table 1. Expression of differentiation and activation markers on re-stimulated CD4+ cells
IFN-g, % posIL4, % posCD25, % pos
CD19-Fc, 1:1003.02.310.3
ephrin-A4-Fc, 1:1001.91.46.1
CD19-Fc, 1:1010.22.619.3
ephrin-A4-Fc, 1:107.42.117.3
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Differential gene expression by integrin β7+ and β7- memory T helper cells
Rodriguez, M., Paquet, A., Yang, Y., Erle, D. (2004) BMC Immunology.
TABLE CAPTION
Table 1. Gene transcripts with higher expression in β7+ versus β7- CD4+ CD45RA- T helper cells
SymbolNameAccessionFold DifferenceP value
CCR9chemokine (C-C motif) receptor 9NM_031200+3.0< 0.01
CCL5chemokine (C-C motif) ligand 5NM_002985+2.4< 0.01
RAM2transcription factor RAM2NM_018719+2.2< 0.01
LRRN3leucine rich repeat neuronal 3AL442092+2.1< 0.01
GFI1growth factor independent 1NM_005263+1.8< 0.01
ITGA4integrin, alpha 4 (CD49D)NM_000885+1.7< 0.01
CD1CCD1C antigen, c polypeptideNM_001765+1.7< 0.01
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Differential gene expression by integrin β7+ and β7- memory T helper cells
Rodriguez, M., Paquet, A., Yang, Y., Erle, D. (2004) BMC Immunology.
TABLE CAPTION
Table 1. Gene transcripts with higher expression in β7+ versus β7- CD4+ CD45RA- T helper cells
SymbolNameAccessionFold DifferenceP value
CCR9chemokine (C-C motif) receptor 9NM_031200+3.0< 0.01
CCL5chemokine (C-C motif) ligand 5NM_002985+2.4< 0.01
RAM2transcription factor RAM2NM_018719+2.2< 0.01
LRRN3leucine rich repeat neuronal 3AL442092+2.1< 0.01
GFI1growth factor independent 1NM_005263+1.8< 0.01
ITGA4integrin, alpha 4 (CD49D)NM_000885+1.7< 0.01
CD1CCD1C antigen, c polypeptideNM_001765+1.7< 0.01
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TABLES EXPANDED